Stelara Gets the Green Light
Monday September 28, 2009
A new option in the fight against psoriasis -- Stelara (ustekinumab). The FDA -- after two long years of talks -- has approved the use of this drug for psoriasis patients who are candidates for phototherapy or systemic treatment, reports MedPage Today. It is to be used for moderate to severe cases. In trials, patients who followed the regimen recommended were able to achieve significantly clear skin for about a year. This is an injectible drug. A few heads up before you talk to your doctor and seek Stelara -- use may cause the immunosupression, and you'll need a TB test before starting to use it.
Raptiva (efalizumab) Pulled From the Market
Monday April 13, 2009
Biologics are one of the
treatment options available for psoriasis. However, psoriasis sufferers will now have to cope with one less option.
Raptiva (efalixumab), a well-know biologic, will no longer be available, according to a press release published by manufacturer Genentech last week.
Genentech is voluntarily pulling the drug from the market in the United States because of, "an increased risk of progressive multifocal leukoencephalopathy (PML), a rare and usually fatal disease of the central nervous system." This will occur in phases, so that doctors have time to safely transition patients to an alternative.
If you're on Raptiva, don't stop taking the medication on your own. Doing so may cause a flare-up, so be sure to contact your healthcare provider to determine your next best steps. Your doctor may recommend that you transition to another biologic psoriasis drug, such as Amevive, Enbrel, Humira or Remicade.
Psoriasis and the Risk of Diabetes
Sunday January 18, 2009
an article in the British Journal of Dermatology (Br J Dermatol. 2008;159(6):1331-1337) looked at the rate of new-onset diabetes developing in patients with psoriasis. They took their data from the UK -based General Practice Research Database. The Risk of developing diabetes was higher in those patients with psoriasis. The severity of the psoriasis was what related to the risk of diabetes, not the BMI (body mass index) which would have related it to obesity instead (another common finding in diabetes). Psoriasis is being looked at more and more as a marker or risk factor for many other serious conditions.
More on Psoriasis and Heart Disease
Sunday January 11, 2009
The current issue of the American Journal of Cardiology contains a consensus document by dermatologists and cardiologists regarding the increased risk of cardiovascular disease in patients with psoriasis. The relationship between heart disease and psoriasis has been noted since 1961. Large epidemiological studies done since then have added support to the idea that psoriasis patients are indeed at risk for heart disease.
The consensus statement recommends that two groups of psoriasis patients be evaluated for vascular disease: those with moderate to severe psoriasis; and those with mild psoriasis plus a recognized risk factor for vascular disease such as abdominal obesity or hypertension.